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Bioanalysis:
Solid-Phase Extraction |
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The
pharmaceutical industry has responded to the challenge of
higher throughput sample preparation by utilizing solid-phase
extraction in a 96-well flow-through microtiter plate format.
The combination of this plate format with automation, and
the proliferation of LC/MS/MS analytical techniques, have
all occurred to create a superior working environment for
the analytical chemist to meet the demands for faster sample
processing and data generation to support the drug development
process. To a lesser extent, automation also exists for the
traditional single disposable columns and cartridges used
for solid-phase extraction, as noted below.
Below
are listed some of the automation choices available to the
pharmaceutical scientist to perform solid-phase extraction
in a high throughput manner.
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| Manufacturer |
Product
Name |
| Applied
Separations |
Spe-ed
Wiz for method development automation using traditional SPE
cartridges |
| Beckman
Coulter |
Biomek
2000 for 96-well SPE plates |
| Caliper Life Sciences |
Sciclone
for 96-well SPE plates
RapidTrace
for traditional SPE cartridges |
| Leap
Technologies |
SPE
Twin PAL for 96-well SPE plates |
| Gilson |
SPE
Model 215 for 96-well SPE plates and traditional SPE cartridges
Cyberlab
C-250 for 96-well SPE plates
ASPEC
XL4 for 96-well SPE plates |
| Hamilton |
Microlab
Series for 96-well SPE plates and for traditional SPE cartridges
|
| Orochem
Technologies |
SpeedPREP
for 96-well SPE plates |
| Packard
BioScience |
MultiPROBE
II (HT/EX) for 96-well SPE plates |
| Spark
Holland |
Prospekt
for on-line SPE |
| Tecan |
Genesis
for 96-well SPE plates |
| Tomtec |
Quadra96
for 96-well SPE plates |
| Zinsser
Analytic |
SPEEDY
for 96-well SPE plates |
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